养血清脑颗粒联合小脑顶核电刺激治疗脑动脉硬化症的疗效观察

Clinical Obsevration of Yangxue Qingnao Granules Combined Fastigial Nucleus Electrical Stimulation in the Treatment of Cerebral Arteriosclerosis

目的观察养血清脑颗粒联合小脑顶核电刺激(FNS)治疗脑动脉硬化症的疗效及可行性。方法82例脑动脉硬化症患者随机分为两组,两组患者均给予常规治疗,治疗组患者在常规治疗的基础上再给予养血清脑颗粒及小脑顶核电刺激治疗,并治疗前后应用经颅多普勒超声和脑干诱发电位监测大脑前、中、后动脉(ACA、MCA、PCA)椎动脉、基底动脉(VA、BA)的血流速度及各波潜伏期及峰间潜伏期的变化。结果(1)治疗组有效率优于对照组;(2)治疗后患者除(PCA)外ACA、MCA、VA、BA的血流速度变化明显,组间比较差异显著(P<0.05);(3)治疗后患者脑干诱发电位(BAEP)中的Ⅰ、Ⅲ、Ⅴ潜伏期(PL)与Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ的峰间潜伏期(IPL)均有不同程度的缩短,组间比较差异显著。结论养血清脑颗粒联合小脑顶核电刺激治疗对脑动脉硬化症有较好的治疗作用。

Objective To explore the effect of yangxue qingnao granules combined fastigial nucleus electrical stimulation（FNS） in the treatment of cerebral arteriosclerosis. Methods 82 patients with cerebral arteriosclerosis were divided into two groups at random, all patients received conventional therapy,besides treatment group also received the therapy of yangxue qingnao Granules and FNS. At the same time, Blood stream velocity of anterior, middle, posterior cerebral artery （ ACA, MCA, PCA ）, vertebral artery （ VA ）, basilar artery （ BA ）, peak latency （PL）and interpeak latency （IPL） were monitored before and after electric stimulation by using transcranial Doppler （TCD）and brainstem evoked potential （BAEP） techniques. Results （1）Efficiency of treatment group was superior to control group. （2）After patients received treatmen! ,there was significant difference in blood stream velocity of ACA,MCA,VA and BA（P〈 0.05）. （3） Ⅰ , Ⅲ, Ⅴ peak latency and Ⅰ - Ⅲ, Ⅲ-V, Ⅰ -Ⅴ interpeak latency of BAEP shortened after treatment, there was significant difference from the control group. Conclusion Yangxue qingnao granules and FNS has favorable treatment effect on patients with cerebral arteriosclerosis.