乐清地区妇女宫颈HPV感染及亚型分布调查研究

Human Papillomavirus Infection in the Married Women and Its Subtype Distribution in Leqing City

目的调查浙江乐清地区妇女宫颈人乳头瘤病毒(HPV)感染及基因亚型的分布情况。方法用专用宫颈刷采取妇女宫颈的脱落细胞,利用基因芯片技术检测23种HPV亚型。结果共检1000人次,HPV感染妇女320人次,感染率为32%,检出HPV亚型515项,高危型感染365例,占感染总数70.87%,高危型感染率排在前5位的依次是16型(15.73%,),18型(8.1%),33型(7.7%),58型(7.3%),59型(5.8%),低危型为150例,感染率为29.1%,单一基因亚型感染203例,占感染人数的63.43%,双重感染70例,占感染人数的21.8%,多重感染47例,占感染人数的14.7%。结论浙江乐清地区妇女宫颈HPV感染率较高,主要为单一感染;感染亚型主要是16和18,其次是33型、58型、59型。

Objective To study the situation of human papillomavirus （HPV）infection in the married females and its subtype distribution. Methods Specimens collected from 1,000 women were used for detecting 23 genotypes HPV by gene chip technology. Results Altogether 320（32%） women were HPV positive among the 1,000 patients. In 320 HPV positive cases,there were 81 cases of HPV-16,42 eases of HPV-18,40 cases of HPV-33 and 38 cases of HPV-58 respectively. 203 cases were single HPV type infection,70 cases were double HPV types infection and 47 cases were multiple HPV types infection, respectively. Conclusion In LeQing City, HPV infection situation of woman was severe. The distinction of HPV genotypes play an important role in prevention and management of CIN and cervical cancer.