大肠肿瘤中CD44V6和P53的表达及意义

Expression and Significance of CD44V6 and P53 in Large Intestine Tumors

目的探讨CD44V6和P53在大肠癌组织和大肠腺瘤组织中的表达情况及其临床病理意义。方法采用免疫组化SP法对41例大肠癌、48例大肠腺瘤手术切除标本的石蜡组织切片进行CD44V6和P53检测。结果CD44V6在大肠癌的阳性表达率为70.7%,P53为53.7%,腺瘤阳性表达率为40.9%和18.2%。结论对大肠腺瘤行CD44V6和P53检测对预测腺瘤恶变和决定手术范围有一定参考意义。

Objective To introduce and discuss the expression and clinical-pathological features of CD44V6 and P53 in colorectum cancer and colorectum adenoma. Methods The expression of two biologic markers ,CD44V6 and P53 ,were detected in paraffin-embedded tissues from 41 cases of colorectum cancer and 48 cases of colorectum adenoma by immuneohistochemical SP method. Results The positive expres- sion rates of the biologic markers were as follows：CD44V6 70.7%,P53 53.7% in colorectum cancer;CD44V6 40.9%,P53 18.2% in colorectum adenoma. Conclusion CD44V6 和 P53 may be the significant predictors foor prognosis of patients with colorectum adenoma,which play a role in evaluation operaton limits.