摘要
目的研究Dusp7基因在急性髓细胞白血病（AML）中的表达及其意义。方法应用实时定量PCR方法检测10名正常健康人、55例AML患者骨髓单个核中Dusp7基因的表达水平及其与临床特征的关系。结果初治、复发组Dusp7基因的表达明显高于正常对照组和完全缓解组（P〈0．05），Dusp7低表达组完全缓解率高于高表达组（P〈0．05），Dusp7基因的表达与患者年龄、性剐、初诊时白细胞数、核型、免疫表型无关。结论Dusp7基因在AML患者中表达增加，Dusp7高表达组完全缓解率明显低于Dusp7低表达组。
Objective To investigate the expression of Dusp7 gene in acute myelogenous leukemia and its clinical significance. Methods By Real-time PCR, the expression ofDusp7 gene of 55 patients with acute myelogcnous leukemia and 10 healthy controls was assayed The relationships between expression of Dusp7 gene and patients＇ clinical characteristics were evaluated. Results Higher level of Dusp7 gene of patients with newly diagnosed AML or relapsed AML was detected （P 〈 0.05） . The CR rate in patients with overexpression of Dusp7 gene was lower （P 〈 0.05） .There were no significant differences between the expression levelof Dusp7 and patients＇ age, sex, WBC, cytogenetic characteristics, immunophenotype （P 〉 0.05）. Conclusions Dusp7 gene was highly expressed in AML.Overexpression of Dusp7 gene in AML might predict poor chemotherapy response.
