雅博司联合拉克替醇散和纳洛酮治疗肝性脑病的临床观察

The study on therapeutic effects of Ornithine Aspartate Injection and Naloxone with Lactitol Powder on hepatic encephalopathy patients

目的研究雅博司联合拉克替醇散和纳洛酮治疗肝性脑病的疗效。方法肝性脑病患者48例,随机分为两组,治疗组24例,对照组24例。治疗前、后测定患者血清氨的含量,并观察雅博司联合拉克替醇散和纳洛酮对肝性脑病疗效。结果治疗前肝性脑病患者血氨含量明显增加,且与肝性脑病程度相关。联合治疗后血氨含量下降程度和肝性脑病清醒时间明显优于对照组,两组相比具有显著性差异(P<0.05)。结论雅博司联合拉克替醇散和纳洛酮对肝性脑病具有明显疗效。

Objective To investigate the therapeutic effects of Omithine Aspartate Injection and Naloxone with Lactitol Powder on hepatic encephalopathy patients. Methods Forty - two patients with HE were divided into two groups ： treat- ment group （24 cases） , control group （24 cases）. Serum levels of NH3 was examined in all patients before and after treatment. The clinical efficacy was also observed. Results Serum levels of NH3 increased markedly in HE and correlated with the severity of HE The decreased serum NH3 level and the time of regaining consciousness were superior to that in the control group （ P 〈 0. 05 ）, and the side effects were slight. Conclusion The Naloxone is a beneficial agent in treatment of hepatic encepha-lopathy safely.