小剂量山莨菪碱在不同年龄段儿童支气管肺炎吸收期应用疗效观察

Effect of low dose anisodamine in the treatment of bronchopneumonia in children with different age

目的探讨小剂量山莨菪碱在不同年龄段儿童中治疗儿童支气管肺炎的疗效。方法将我院2007年10月-2008年l0月148例支气管肺炎患儿分成对照组(69例)及治疗组(79例),且按不同年龄将治疗组患儿分为<1岁组、1-3岁组及>3岁组。对照组采用综合治疗,治疗组在此基础上加用山莨菪碱静滴,连续用7d。观察主要症状、体征、实验室检查和药物不良反应。结果治疗组患儿临床症状、体征及血气分析结果的好转时间较对照组明显缩短(P<0.05),总有效率明显高于对照组(P<0.05)。同时,在≤3岁患儿中的疗效更优于3岁以上患儿。结论联合应用小剂量山莨菪碱治疗儿童支气管肺炎,特别是年龄<3岁患儿,有明显通畅呼吸道、改善咳喘症状、消除肺部啰音、缩短病程的疗效。

Objective To investigate the clinical effect of the combining therapy low dose anisodamine in the treament of children bronchopneumonia. Methods 148 children with bronehopneumonia were divided into two group ： treatment group （ n = 79 ） and control group （ n = 69 ）. In addition, according to the age, children in the treatment group were further divided into 〈 1 year group, 1 - 3 year group and 〉 3 year group. The control group was treated with conventional therapy, while the treatment group was treated with conventional therapy combining with low dose anisodamine. After 7 days, the symptoms, physical signs, laboratory examination and drug adverse reaction were observed. Results Compared with those in control group, PaO2 and pH value increased significantly, symptoms and physical signs in respiration improved significantly, duration of hospitalization and PaCO2 decreased significantly after treatment in the treatment group （ P 〈 0.05 ）. Additionally, patients less than three years old achieved better therapeutic effect than the older （ P 〈 0.05 ）. Conclusion The combination with lose dose anisodamine is effective as an adjuvant therapy for children bronchopneumonia, especially in patients less than three years old.