1例急性铀中毒案例的33年医学随访

A 33-year Medical Follow-up to Patient with Acute Uranyl Nitrate Hexahydrate Poisoning

本文报道对1例硝酸铀酰复合烧伤致急性铀中毒案例进行了33年的医学随访,以观察和研究人体急性铀中毒后的远期效应。随访期间研究观察的内容:①主诉症状和其尿铀检测;②临床实验室检查:外周血像及骨髓像,肾功能,肝功能,对细胞遗传学的影响,用放免分析方法检测甲状腺、肾上腺的内分泌功能,免疫功能检查包括细胞免疫功能和体液免疫功能,代谢功能检查包括糖耐量试验、胰岛素释放试验、脂代谢,细胞化学检查包括淋巴细胞糖元和粒细胞碱性磷酸酶,神经系统损伤效应,心肺等功能检查;③L的生育能力和遗传效应,及对其子女的随访。结果表明:外周血及骨髓功能正常;肾功能基本恢复;肝功能正常;淋巴细胞染色体畸变率检有染色体型畸变和染色单体畸变;细胞遗传学检查有环状体、双着丝粒体及断片等染色体型畸变,还有以单体断片和碎片为主的染色单体畸变;其他检查如甲状腺、肾上腺内分泌功能,细胞和体液免疫功能,代谢功能检查、淋巴细胞糖元和粒细胞碱磷酶检查基本正常;生育能力未受影响,子女体质差,疾病易感性高、抗病毒能力差;儿子不育,女儿妊娠期胎儿发育不良。

A 33-year medical follow-up to the patient with acute uranyl nitrate hexahydrate poisoning and his children. The result shown that the function of peripheral blood, liver, kindey and bone marrow were normal, Chromosome aberration with ring, fragment, dicentric and chromatid aberration with single strand break, splinter of lymphocyte occurred, followed by other examinations such as thyroid, endocrine characteristic of adrenal gland, NAP potentia generandi were normal, while his children were sensitive to disease, so son was kakogenic, and daughter had dysplastic embry.