大剂量纳洛酮治疗老年人急性重型脑外伤患者的疗效分析

Clinical efficacy of naloxone hydrochloride on elderly acute severe brain injury

目的:探讨大剂量盐酸纳洛酮对老年人急性重型脑外伤后患者的临床疗效。方法:86例老年急性重型脑外伤患者随机分为盐酸纳洛酮治疗组43例和对照组43例,观察治疗后患者颅内压(ICP)及GCS(格拉斯哥昏迷指数)评分,同时对比6个月时患者的GOS(预后评分)。结果:治疗组颅内压较对照组显著降低(P<0.05),GCS评分较对照组明显改善(P<0.05),6个月后GOS评分均明显好于对照组(P<0.05)。结论:盐酸纳洛酮可明显减轻老年急性重型脑外伤患者颅内高压,降低病死率和病残率。

Objective：To asses the clinical effects of naloxone hydrochloride in treatment of elderly acute severe brain injury. Methods：86 elderly patients with severe brain injury were randomly divided into two groups：43 patients treated with naloxone hydrochloride in the treatment group and 43 patients treated on routine in the control group. ICP, GCS and long-term effects （GOS） of two groups were compared. Results：ICP in the treatment group was lower than that of the control group （P〈0.05）. GCS in the treatment group was significantly better than that of the control group（P〈0.05）.Evaluation of GOS in the treatment group was better than that of the control group （P〈0.05）. Conchlsion：Naloxone hydmchloride could lower ICP,reduce the motality and the disability in the elderly patients with acute severe brain injury.