影响慢性重型肝炎预后因素分析

Analysis of prognostic factors for chronic severe hepatitis

目的:探讨影响慢性重型肝炎预后的因素。方法:回顾性分析2002～2004年我院肝病中心治疗的60例慢性重型肝炎患者的临床资料。结果:⑴恶化死亡组与好转组年龄,两组比较有差异,恶化组年龄大。⑵随着总胆红素(TIBL)不断升高,总胆固醇(CHO)、凝血酶原活动度(PTA)、纤维蛋白原(FIB)不断降低,病死率越高。⑶36例患者MELD分值>20分,其病死率与MELD预期病死率无差别。结论:年龄、TBIL、CHO、PTA、FIB是影响慢性重型肝炎预后的重要因素。MELD可以较准确地预测慢性重型肝炎的病死率,为进一步治疗决定肝移植的分配奠定了基础。

Objective ：To study the related factors influencing the prognosis of chronic severe hepatitis.Methods：Between 2002 and 2004,60 patients with chronic severe hepatitis were retrospectively ceviewed. Results： （1）The older age the patient was,the higher fatality rate there was. （2）The fatality rate increased gradually with TBIL and decreased in prothrombin activity （PTA）.total cholesterol （CHO）and FIB.（3）There was no significant difference （P〉0.05） in the fatality rate in case with the MELD score〉20 and predicting mortality. Conclusion：The important factors related to prognosis are TBIL.PTA,CHO, FIB.The MELD can accurately predict the fatality rate in the patients with severe hepatitis.