摘要
经典的肾素血管紧张素系统在维持动脉血压平衡，水电解质平衡，调节细胞增生及分化中起着重要的作用。血管转化酶2，血管紧张素1-7的受体Mas等新成员的发现使人们对这一系统的认识进一步深化。血管紧张素1-7，及其在体内主要的合成酶ACE2，和受体Mas组成的调节轴可产生广泛的生理学效应，拮抗血管转化酶-血管紧张素Ⅱ-AT1受体调节轴的效应，从而为高血压，心衰等心血管疾病和肾脏，肝脏等系统疾病的药物治疗提供新的思路和方法。
The classic system of renin - angiotensin system plays an important role in regulating arterial blood pres- sure, water - electrolyte balance, cellular proliferation and differentiation. The recent discoveries of new components of this system such as ACE2 and Mas receptor deepen our research in the system. Angiotensinl -7, its syozyme ACE2 and its recep- tor Mas constitute an axis which can evokes many protective effects. This axis has a counter - regulatory role towards the ACE - AngⅡ- AT1R axis. It can open great potential in treating the cardiovascular diseases such as hypertension and chronic heart diseases, and other systemic diseases such as in kidney and liver.
出处
《中国医学创新》
CAS
2009年第16期160-163,共4页
Medical Innovation of China
基金
国家自然科学基金资助项目（No.30671001）
