噻嗪类利尿剂及氯沙坦对原发性高血压的血清尿酸水平的影响

Effect of thiazide diuretics and losartan on serum uric acid in essential hypertension

目的:观察原发性高血压患者分别服用噻嗪类利尿剂、氯沙坦4周后血清尿酸的变化。方法:对在我院连续诊疗的原发性高血压患者128例随机分为利尿剂组和氯沙坦组,利尿剂组63例,氯沙坦组65例。结果:两组药物均能明显降低患者的血压,且两组降压幅度无明显差异。利尿剂组治疗后尿酸平均升高41.67μmol/L(P<0.01),氯沙坦组平均下降30.47μmol/L(P<0.01),两组药物治疗后尿酸之间的差异有显著性。结论:噻嗪类利尿剂会升高原发性高血压病患者尿酸水平,氯沙坦可降低原发性高血压患者的尿酸水平。

Objective ：To survey the serum uric acid changes after 4-week antihypertensive treatment with thiazide diuretics,losartan in the patients with essential hypertension. Methods：A total of 128 consecutive patients with essential hypertension were allocated randoraly to diuretics group （n=63）, losartan group （n=65）. The blood pressure and serum uric acid,before and after antihypertensive treatments,were obtained in all patients. Results ：Two groups,diuretics group and losartan group,could significantly lower blood pressure, and the range of lowering blood pressure had no significant difference. Serum uric acid was significantly increased （41.67 umol/L） in diuretics group（P〈0.01）,but significantly reduced （30.47 umol/L） in losartan group（P〈0.01）. Conclusion：The thiazide diuretics could further aggravate hyperurieaciduria while losartan could reduce hypemfieaeiduria in the patients with essential hypertension.