小儿过敏性咳嗽与肺炎支原体感染的相关性探讨

Investigation on correlation between allergic cough and mycoplasma pneumoniae infection in children

目的:探讨小儿过敏性咳嗽与肺炎支原体(MP)感染的关系及大环内酯类药物治疗的效果。方法:选择我院儿科门诊及住院的过敏性咳嗽患儿89例为观察组,99例同期就诊、年龄相仿的急性上呼吸道感染患儿为对照组A,以及儿童保健科正常体检小儿86例为对照组B。3组患儿均应用颗粒凝集法测定MP-IgM。观察组MP-IgM阳性者应用阿奇霉素治疗。结果:观察组MP-IgM阳性率为40.4%;对照组AMP-IgM阳性率为12.1%;对照组BMP-IgM阳性率为8.1%。36例过敏性咳嗽并MP感染的患儿在常规哮喘治疗基础上,加用阿奇霉素口服,总有效率为83.3%。随访6～12个月,仅4例轻度咳嗽发作。结论:小儿过敏性咳嗽与肺炎支原体感染关系密切,过敏性咳嗽并MP感染的患儿在常规治疗基础上加用大环内酯类药物疗效明显。

Objective： To explore the correlation between allergic cough and mycoplasma pneumoniae （MP） in children and the effect of macrolide treatment. Methods： 89 children with allergic cough were selected as observation group, 99 children with acute upper re- spiratory tract infection and 86 healthy children were selected as control group A and control group B. The levels of MP - IgM in three groups were detected by particle agglutination method. Children in observation group with positive MP - IgM were treated by azithromycin. Results： The positive rates of MP - IgM in observation group, control group A and control group B were 40.4%, 12. 1% and 8.1% , respectively, the total effective rate of azithromyein in 36 children of allergic cough was 83.3% , only four children of mild cough attack after 6 - 12 follow - up. Conclusion： The pediatric allergic cough is related to mycoplasma pneumoniae infection, conventional therapy plus maerolide drugs is effective.