急进高原4600m健康成人血氧代谢酶和急性轻症高原病评分相关性分析

Correlation between Blood Oxygen-Metabolizing Enzymes and Mild Acute Mountain Sickness Score in Healthy Adult Acute Exposed to 4600m Altitudes

目的:初步探讨急进高原健康成人血氧代谢酶和急性轻症高原病评分之间的相关性分析。方法:对急进到海拔4 600m地区身体健康的成年人进行血氧代谢酶检测并同时给予急性轻症高原病评分,两者之间进行相关性分析。结果:谷胱甘肽(glutathione,GSH)、谷胱甘肽过氧化物酶(glu-tathione perioxidase,GSH-PX)、丙二醛(malonaldehyde,MDA)、过氧化物歧化酶(superoxide dis-mutase,SOD)和急性轻症高原病评分分度之间无明确的相关性,过氧化氢酶(Catalase,CAT)与急性轻症高原病评分分度有着显著的正相关,而环腺苷酸(cyclase adenosine monophosphate,c-AMP)与急性轻症高原病评分分度却有着显著的负相关。采用急性轻症高原病评分计分与各血氧代谢酶进行线性相关分析,未发现有明确直线相关关系。结论:我们认为急进同一特高海拔地区时,CAT和c-AMP这两项血氧代谢酶和急性轻症高原病评分分度之间相关性较强。

Objective： To study primarily the correlation between the blood oxygen--metabolizing enzymes and the mild acute mountain sickness score in healthy adults rapidly ascended to high altitudes. Methods： The blood level of oxygen--metabolizing enzymes of the healthy adults whom were exposed acutely to 4,600m high altitudes were measured, and features of acute manifestation to high altitude were recorded and the assessment of the results was conducted to the correlation between the both .sections. Results： There was no obvious correlation between the GSH, GSH--PX, MDA, AOD index and the mild acute mountain sickness score; on the contrary, the CAT was significant. The c--AMP was negative significantly correlated with the score. The results suggested that mild acute mountain sickness was not correlated to the blood oxygen--metabolizing enzymes by linear correlative analysis Coclusions：When the healthy adults are acutely exposed to high altitude the level of CAT or c--AMP （blood oxygen--metabolizing enzymes） is strongly correlated with the mild acute mountain sickness score.