摘要
目的探讨中国北方汉族健康人群5-HT1A受体C(-1019)G基因多态性对人格的影响。方法严格按照入组标准筛选中国北方汉族健康人群404例.采用艾森克人格问卷(EPQ)测量人格的3个维度,聚合酶链反应(PCR)检测5-HT1A受体C(-1019)G基因多态性,使用SPSS13.0统计软件进行统计分析。结果①5-HT1A受体C(-1019)G不同基因型间神经质人格维度均数差异有显著性伊=3.868,P=0.022);携带C等位基因者神经质分值[(44.77±10.91)分]高于G等位基因[(42.71±9.95)分],差异具有显著性(t=2.466,P=0.014)。②5-HT1A受体C(-1019)G不同基因型间精神质人格维度均数差异有显著性(F=3.145,P=0.044);携带C等位基因者精神质分值[(47.14±8.74)分]高于G等位基因[(45.42±8.58)分],差异有显著性(c=2.403,P=0.017)。不同精神质维度分组间,5-HT,。受体C(-1019)G各基因型频数分布差异有显著性(x2=9.293,P=0.009);C等位基因在精神质组频数分布(86.4%)高于非精神质组(74.1%),差异有显著性(x2=7.818,P=0.005,OR=2.22)。③5-HT1A受体C(-1019)G各基因型及等位基因间内外向人格维度均数均差异无显著性(P〉0.05);内外向各分组间,不同基因型及等位基因频数分布也均差异无显著性(P〉0.05)。结论5-HT1A受体C(-1019)G基因多态性与神经质、精神质人格相关联,且等位基因C是二者的可疑危险因素。尚未发现5-HT1A受体C(-1019)G基因多态性与内外向人格相关联。
Objective To analyze the association between 5-HTR1A C (-1019) G polymorphism and EPQ personality dimensions. Methods 404 Han Chinese healthy volunteers were assessed by EPQ personality ques- tionnaire including P, E, N dimensions. All were genotyped for 5-HTR1A C (-1019)G variants with PCR. Result- s Among various C(-1019)G genetypes, the difference in N dimension means was significant (F = 3. 868, P = 0. 022 ) , and P dimension means were also significantly different(F = 3. 145, P = 0. 044 ). N dimension score with C allele (44.77 ± 10.91 ) was higher than with allele G (42.71± 9.95 ) , which had statistic significance ( t = 2. 466, P=0.014). P dimension score with allele C(47.14±8.74) was also higher than with G allele(45.42±8.58) , which was significant( t= 2. 403, P= 0.017). The distribution variance of C(-1019) G genetypes between differ- ent P dimension groups had significance ( X2 = 9. 293, P = 0. 009 ). The C allele frequence in the psychotieism group ( 86.4% ) was higher than non-psyehotieism group (74.1% ) , the variance was significant ( X2 = 7.818, P = O. 005, OR = 2.22 ). In contrast, no association was detected between the polymorphism and E dimension (P 〉 0.05 ). Conclusion The present study shows significant associations between the 5-HTR1A C(-1019) G and N or P dimension, and C allelic is possibly one of risk factors of neuroticism or psyehoticism. No relation is found be- tween the polymorphism and extraversion.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2009年第5期392-394,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
基金项目:国家自然科学基金(30770770)
山西省科技攻关项目(2007031091.3)
国家人事部留学回国人员科研资助项目(200748)
山西省自然科学基金(2007011120)