5-HT1A体C（-019）G基因多态性与神经质及精神质人格关联分析

Association between the serotonin 1A receptor gene polymorphism and personality

目的探讨中国北方汉族健康人群5-HT1A受体C（-1019）G基因多态性对人格的影响。方法严格按照入组标准筛选中国北方汉族健康人群404例．采用艾森克人格问卷（EPQ）测量人格的3个维度，聚合酶链反应（PCR）检测5-HT1A受体C（-1019）G基因多态性，使用SPSS13．0统计软件进行统计分析。结果①5-HT1A受体C（-1019）G不同基因型间神经质人格维度均数差异有显著性伊=3．868，P=0．022）；携带C等位基因者神经质分值[（44．77±10．91）分]高于G等位基因[（42．71±9．95）分]，差异具有显著性（t=2．466，P=0．014）。②5-HT1A受体C（-1019）G不同基因型间精神质人格维度均数差异有显著性（F=3．145，P=0．044）；携带C等位基因者精神质分值[（47．14±8．74）分]高于G等位基因[（45．42±8．58）分]，差异有显著性（c=2．403，P=0．017）。不同精神质维度分组间，5-HT，。受体C（-1019）G各基因型频数分布差异有显著性（x2=9．293，P=0．009）；C等位基因在精神质组频数分布（86．4％）高于非精神质组（74．1％），差异有显著性（x2=7．818，P=0．005，OR=2．22）。③5-HT1A受体C（-1019）G各基因型及等位基因间内外向人格维度均数均差异无显著性（P〉0．05）；内外向各分组间，不同基因型及等位基因频数分布也均差异无显著性（P〉0．05）。结论5-HT1A受体C（-1019）G基因多态性与神经质、精神质人格相关联，且等位基因C是二者的可疑危险因素。尚未发现5-HT1A受体C（-1019）G基因多态性与内外向人格相关联。

Objective To analyze the association between 5-HTR1A C （-1019） G polymorphism and EPQ personality dimensions. Methods 404 Han Chinese healthy volunteers were assessed by EPQ personality ques- tionnaire including P, E, N dimensions. All were genotyped for 5-HTR1A C （-1019）G variants with PCR. Result- s Among various C（-1019）G genetypes, the difference in N dimension means was significant （F = 3. 868, P = 0. 022 ） , and P dimension means were also significantly different（F = 3. 145, P = 0. 044 ）. N dimension score with C allele （44.77 ± 10.91 ） was higher than with allele G （42.71± 9.95 ） , which had statistic significance （ t = 2. 466, P=0.014）. P dimension score with allele C（47.14±8.74） was also higher than with G allele（45.42±8.58） , which was significant（ t= 2. 403, P= 0.017）. The distribution variance of C（-1019） G genetypes between differ- ent P dimension groups had significance （ X2 = 9. 293, P = 0. 009 ）. The C allele frequence in the psychotieism group （ 86.4% ） was higher than non-psyehotieism group （74.1% ） , the variance was significant （ X2 = 7.818, P = O. 005, OR = 2.22 ）. In contrast, no association was detected between the polymorphism and E dimension （P 〉 0.05 ）. Conclusion The present study shows significant associations between the 5-HTR1A C（-1019） G and N or P dimension, and C allelic is possibly one of risk factors of neuroticism or psyehoticism. No relation is found be- tween the polymorphism and extraversion.