摘要
本文Ｐ２１ｒａｓ免疫组化采用链霉菌抗生物素蛋白——过氧化酶（ＳＰ）法检测了６１例胃粘膜标本。结果表明胃癌（５６．０％）与胃癌前病变（６０．０％）阳性率高于胃良性病变（１４．０％），Ｐ值分别＜０．０５与＜０．００５。并进行了诊断胃癌价值评估，其敏感性、特异性和准确性分别为５６．０％，６６．７．与６２．３％，说明Ｐ２１ｒａｓ诊断胃癌有一定价值。同时检测了幽门螺旋杆菌（ＨＰ），计算Ｐ２１ｒａｓ阳性与ＨＰ感染的相关系数为０．８７９，呈正相关。
The expression of ras Oncogene P 21 Protein in 61 benign and malignant diseases of the stomach was studied by streptavidin Peroxidase(SP) method.The results showed that expression of ras P 21 was higher in gastric carcinoma and early gastric carcinoma than in benign diseases.The sensitivity specificity and accuracy for diagnosing stomach cancer was 56%、66.7% and 62.5% respectively.These findings indicate that ras P 21 overexpression may be related to events of human gastric carcinomas.Helicobacter Pylori(HP) infection was assayed.The results suggest that there is a positive correlation between HP infection and ras P 21 overexpression.
关键词
P^ras21
胃癌
诊断
幽门螺杆菌
oncogene protein P 21
gastric carcinoma
diagnosis
helicobacter pylori
