大肠癌细胞生长抑素的表达与Fas及其信号系统的关系

Relation between Expression of Samotostatin and Fas with Its Information Systemin Colorectal Carcinoma

目的研究大肠癌细胞生长抑素的表达与Fas及其信号系统的关系。方法采用免疫组化方法检测60例大肠癌细胞的生长抑素及Fas,caspase-8,caspase-3的表达情况,并分析它们之间的关系。结果在60例大肠癌细胞中,Fas,caspase-8,caspase-3在生长抑素高表达组中的表达均比低表达组高。结论生长抑素在大肠癌细胞中可能是通过提高Fas受体的表达或增加其信号系统的敏感性来促进癌细胞的凋亡。

Objective To study the relation between the expression of somatostatin and Fas with its information system in colorectal carcinoma. Methods The expression of somatostatin, Fas, caspase- 8, caspase- 3 in 60 cases of coloreetal carcinoma was studied immunohistochemically. Results In 60 cases of colorectal carcinoma, the expression of Fas, caspase- 8, caspase- 3 was higher in the group with high expression of somatostatin than the group with low expression of samatostatin（ P〈0. 05）. Conclusion High expression of somatostatin may mediate apoptosis of colorectal cancer cells by improving the expression of Fas and sensitizing its information system.