日本血吸虫病合并HBV和HCV感染血清肝纤维化指标的变化及意义

The effect of HBV and HCV on liver fibrosis formation of schistosomiasts japonica

目的：探讨ＨＢＶ和ＨＣＶ对日本血吸虫病肝纤维化的影响。方法：用放免和酶标法分别测定晚血、慢血和自然人群血清的ＨＢＳＡｇ和抗ＨＣＶ，分成ＨＢＳＡｇ阳性组，抗ＨＣＶ阳性组和双阴性组，用放免法和生化法测定其血清肝纤维化指标即透明质酸（ＨＡ）、层粘蛋白（ＬＮ）、Ⅲ型前胶原（ＰＣⅢ）、谷胱甘肽Ｓ转移酶（ＧＳＴ）。结果：晚血的肝纤维化指标显著高于慢血，后者又显著高于自然人群。晚血的ＨＢｓＡｇ和抗－ＨＣＶ阳性组的ＨＡ、ＬＮ和ＰＣⅢ均显著高于阴性组，慢血的ＨＢｓＡｇ和抗－ＨＣＶ阳性组的ＰＣⅢ显著高于阴阳组，而ＨＡ和ＧＳＴ没有。

Aims: To investigate effect of HBV and HCV on formation schistosomiasis japonica.Method: Serum samples collected from late and chronic cases of schistosomiasis japonica as well as normal persons (served as control), were detlected for HBSAg by radioimmunoassay(RIA), anti-HCV by ELISA. The patients were then divided into HBsAg-Positive,anti-HCV-positive and negative groups, all were tested for sera hyaluronate(HA),type l l l proco-llage(pclll),laminin(LN)by RIA,and glutathione-s-transferase(GST) by biochemical analysis. Result: The values of HA,LN,PClll in the patients with late schistosomiasis were significantly higher than those of the patients with chronic schistosomiasis and the controls.Of the late schistosomiasis,these values in the HBsAg and anti-HCV positive group were significantly higher than those in the negative group.The valuse of PCⅢ, HA,GST in the chronic schistosomiasis cases were significamtly higher than those in the control. Of the chronic schistosomiasis,the value of PClll,not HA and GST in the HBsAg and anti-HCV posotive group was significantly higher than that in the negative groups.Conclusion: HBV and HCV might play a role in promoting liver fibrosis formation in schistosomiasis japonica