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肝炎肝硬化的骨钙素、甲状旁腺素、降钙素的变化及其临床意义 被引量:1

Determination of osteocalcin,parathyroid hormone.calcitonin in cirrhosis and its clinical significance
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摘要 目的:为了解肝硬化骨病的形成机理。方法:本文采用放射免疫法对35例肝炎肝硬化的血清进行了骨钙素、甲状旁腺素(PTH)及降钙素(Calcitonin)的测定。结果:肝硬化患者的骨钙素(Gal)明显高于正常对照(P<0.01),PTH也高于正常,血钙低于正常,但均无统计学意义(P<0.05),各激素与血清白蛋白、凝血酶原时间及总胆红素之间无明显相关。按Child分级,C级患者的Gal及PTH明显高于A级及B级患者,而血钙浓度低于A级及B级。结论:肝硬化对骨病的产生与所测三种激素的代谢紊乱有密切关系。 Aim: In order to understand the mechanism that can account for osteopenia in liver cirrhosis, Thirty five patients with liver cirrhosis were studied.Methods: Osteocalcin (Gal),parathyroid Hormone (PTH) Calcitonin were determined in serum of patients with liver cirrhosis by radio-immunoassay. Result:In 35 cirrhosis, mean concentration of Gal was significantly increased compared to normal controls (P<0.01),mean concentration of PTH was higher and that of serum calcium was lower than normal controls,but significant differcnce was not reached. No correlation was found between every hormone measured and serum albumin, prothrombin time and total bilirrubin. Gal level and PTH level in patients with C grade of child classification were significantly higher than that in patients with A and B grade. Concentration of serum calcium in C grade was significantly reduced compared with A and B grade.Conclusion: These data suggested that development of osteopenia in cirrhosis was closely associated with metabolic disturbance of every measured hormone. Hypocalcemia possibly caused by malabsorption of calcium maybe play an important role in leading to osteopenia in liver cirrhosis.
出处 《胃肠病学和肝病学杂志》 CAS 1998年第2期145-147,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 肝硬化 骨钙素 甲状旁腺素 病理 Liver cirrhosis Osteocalcin Parathyroid hormone Calcitonin
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