肝炎平对大鼠慢性肝损害胶原纤维作用的实验研究

An Experimental study On the Effect of Gan Yanping on Collagen Fiber in Rat Chronic Liver Induced By CCl 4

目的与方法：采用四氯化碳（ＣＣｌ４）诱导的大鼠慢性肝损伤的模型，观察肝炎平对大鼠血清ＡＬＴ、ＡＳＴ的活性及γ球蛋白含量的影响及其对慢性肝损伤的保护作用。结果：结果表明：肝炎平组血清ＡＬＴ活性为１０２０７±１５０２ｕ／Ｌ、ＡＳＴ为９３０１±２４０８ｕ／Ｌ，γ球蛋白含量为０２０３±００１３，模型组的血清ＡＬＴ、ＡＳＴ活性及γ球蛋白含量分别为１４７０５±１４０３、１３５０６±３７４及０２４３±００２６。Ｐ＜００１。肝组织中胶原增生的总面积肝炎平组为９２９０１±１６５５，面积百分数为５７３±１１１。而模型组胶原增生的总面积则为１６０１５５±２８１８５，面积百分数是９１９±１６７，Ｐ＜００１。结论：肝炎平能减轻肝细胞的损伤，抑制胶原的增生，有防治肝纤维化的作用。

Aim: The protective effect of GanYanping(GYP) on chronic liver injury induced by CCL 4 was studied.Methods:The 33 rats were divided into control group,model group(N.S+CCI 4),experimental group (GYP+CCL 4).Results:The experimental results showed that the serum ALT activity、AST activity and the content of collegen in the liver tissue were markedly decreased in Gan Yanping group comparied with model proup.It is significantly different (P<0.01).Conclusions:These findings suggest that GYP can lighten injury of liver cells,inhibit college fibre synthesis,prevent the effect of liver fibrosis.