热休克蛋白HSP70、90α在非霍奇金淋巴瘤中的表达及临床意义

Expressions of heat shock protein 70 and 90α in non-Hodgkin's lymphoma and its clinical significance

目的研究热休克蛋白(HSP)70、90α在非霍奇金淋巴瘤(NHL)中的表达并探讨其意义。方法应用免疫组化法检测HSP70、90α在30例NHL组织中的表达,并结合临床指标进行分析。10例坏死性淋巴结炎和12例淋巴结反应性增生组织作为对照。结果HSP70、90α在NHL、坏死性淋巴结炎和淋巴结反应性增生组织中均有高水平表达。HSP70高表达(阳性率大于50%)与NHL恶性程度、分期及治疗反应密切相关(P<0.05),与是否有B症状、是否累及结外无关(P>0.05)。HSP90α高表达与上述指标无相关性(P>0.05)。结论检测NHL组织中HSP70的表达程度有助于判断NHL的恶性程度、分期及治疗反应。

Objective To study the expressions of heat shock protein 70 and 90α in non-Hodgkin＇s lymphoma（NHL） and their chnical significance. Methods Expressions of HSP70 and HsP90a were evaluated in 30 NHL by immunohistochemical staining. 10 necrotic lymphnoditis and 12 reactive hyperplastic lymphnodes were used as controls. Results There were no significant dif- ferences in expressions of HSP 70 and HSP90α among NHL, necrotic lymphnoditis, and reactive hyperplastic lymphnedes. High expression of HSP70 （ positive cell 〉 50 % ）was correlated with the degree of malignancy, stage and therapy reaction（ P 〈 0.05）, butwas not related to B syndrome and extra-lymphonode infestation（ P 〉 0.05）. No relationship was found between high expres- sion of HSPgOa and Clinical characters（P〉 0.05）. Conclusion HSP70 may be a useful indicator for evaluation of malignancy, stage, and therapy reaction of NHL.