山东地区宫颈癌危险因素病例对照研究

Risk factors of cervical cancer in Shandong Province:a case-control study

目的探讨山东地区宫颈癌发病危险因素。方法采用以医院为基础的1:2病例对照研究,用统一的调查表对山东省三所省级医院893例宫颈癌患者及1786例对照进行调查,应用条件Logistic回归分析筛选宫颈癌发病危险因素。结果在单因素Logistic回归分析的基础上,HPV16感染、HPV52感染、吸烟、首次性交年龄、性伴侣个数、人工流产次数、配偶有阴茎癌或前列腺癌、绝经和使用避孕套共9个因素被引入回归模型,其OR值依次为:28.256、10.164、2.946、4.529、4.012、4.211、1.312、0.507和0.612。结论HPV16、HPV52感染是山东地区宫颈癌发生的主要危险因素,首次性交年龄早、性伴侣个数多、人工流产次数多、吸烟以及配偶有阴茎癌或前列腺癌可增加宫颈癌发生的危险,而绝经和使用避孕套则降低宫颈癌的发生风险。

Objective To investigate risk factors of cervical cancer in Shandong Province and to provide a scientific basis for monitoring and preventing this disease. Methods A 1 ： 2 matched case-control study including 893 cases with cervical cancer and 1786 controls was carried out in Shandong Province. Data were analyzed with conditional logistic regression. Results Based on monovariate analysis results, multivariate logistic analysis was used. HPV16 infection, HPV52 infection, smoking, age of first intercourse, number of sexual partners, number of induced abortions, spouse with penile cancer or prostatic cancer, post-meno- pause, and condom usage were selected into the module. The OR value respectively was 28.256, 10. 164, 2.946, 0.507, 4.529, 4.012, 4.211, 1.312, 0. 507 and 0.612. Conclusion I-IPV16 and HPV52 infection play important roles in the devel- opment of cervical cancer in Shandong Province. Young age at first intercourse, larger number of sexual partners, larger number of induced abortion, smoking and spouse with penile cancer or prostatic cancer are risk factors of cervical cancer. However, post- menopause and condom use are protective factors against cervical cancer.