GSTM1基因多态性与子宫内膜异位症易感性的相关性研究

Relationship Between Glutathione S-transferase M1 gene Polymorphism and Susceptibility to Endometriosis

【目的】探讨谷胱甘肽S转移酶M1（GSTMI）基因多态性与子宫内膜异位症（EM）易感性的关系。【方法】应用内参照PCR技术检测96例Eros患者和88例对照妇女的GsTM1基因型。【结果】病例组GSTMI（-）频率为65．6％（63／96），对照组为45．5％（40／88），两组之间有非常显著性差异（P〈0．01），其OR值为2．29（95％CI为1．27-4．15），具有GsTM1（-）的个体患Eros的危险性增加1．29倍；病例组中Ⅰ-Ⅱ期与Ⅲ-Ⅳ期患者的GSTM1（-）频率无显著性差异（P〉0．05），Ⅰ-Ⅱ期与对照组也无显著性差异（P〉0．05），但Ⅲ-Ⅳ期患者与对照组有显著性差异（P〈0．01）。【结论】GSTM1基因多态性与Eros易感性有关，GSTM1（-）可能参与了Eros的致病过程。

[Objective]To study the relationship between glutathione S-transferase M1 （GSTM1） gene polymorphism and susceptibility to endometriosis （EM）. [Methods]The GSTM1 genetypes of 96 patients with EM and 88 controls were detected by multiple PCR techniques. [Results]The frequency of GSTMI（-） was 65.6 % （63/96） in the patients and 45.5 % （40/88）in controls, and the difference was statistically significant （ P d0.01）. The odds ratio was 2.29（95%CI=1.27~4. 15） ,which suggested that the person with GSTMI（-） had 1.29 times of increased risk of EM. The difference in the frequency of GSTM1 （-） was not significant between the patients with Ⅰ-Ⅱand patients with Ⅲ-Ⅳ（ P 〉0.05）, also between the patients with Ⅰ-Ⅱ and the control （ P 〉0. 05）, but the difference was statistically significant between the patients with Ⅲ-Ⅳ and the control（ P〈0. 01）. [Conclusion] There is a remarkable relationship between GSTM1 gene polymorphism and susceptibility to EM, which is a possible involvement of GSTM1 （-） in the development of EM.