摘要
【目的】通过观察急性脑梗死(ACI)患者血清巨噬细胞移动抑制因子(MIF)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)水平的动态变化,探讨其在ACI发病中的作用及临床意义。【方法】采用酶联免疫吸附法(ELISA)对60例ACI患者发病后d1、d6、d14血清MIF、TNF-α、IL-8水平进行测定,并与40例正常人做对照。【结果】ACI组1-14d各时点血清MIF、TNF-α、IL-8水平均升高,以d6增高最为明显,与对照组比较,差异均有显著性(P〈0.05或0.01);ACI重型患者各时间点血清MIF、TNF-α、IL-8水平显著高于中型、轻型患者(P〈0.05或0.01),中型患者各时间点MIF、TNF-α、IL-8水平明显高于轻型患者(P〈0.05);ACI组MIF与TNF-α及IL-8均呈正相关(P〈0.05),但TNF-α与IL-8之间无相关性(P〉0.05)。[结论]MIF、TNF-α、IL-8可能参与ACI发病过程,并可作为病情判断及预后的观察指标。
[Objective]To investigate the changes of levels of serum macrophage migration inhibitory factor (MIF), tumor necrosis factor-α(TNF-α) and interleukin-8(IL-8) in the patients with acute cerebral infarction (ACI), and to assess their effect and clinical significance. [Methods] The serum levels of MIF,TNF-αand IL- 8 were detected by ELISA on day 1, 6 and 14 in 60 patients with ACI, and 40 normal healthy people were as controls. [Results] The serum levels of MIF,TNF-α and IL-8 in ACI group were significantly increased compared with control group ( P〈0. 05 or 0.01), and peaked on day 6. The serum levels of MIF,TNF-α and IL- 8 of patients with serious ACI were significantly higher than those of middle and mild ACI patients ( P〈0.05 or 0.01), and those of middle ACI patients were higher than those of mild ACI patients( P 〈0.05). Serum MIF levels showed positive correlation with serum TNF-α and IL-8 levels, but there was no correlation between TNF-α and IL-8( P〈0.05)in ACI group. [Conclusion] MIF, TNF-α and IL-8 may participate in the pathogenesis of ACI, and they can be new indicators for evaluating the severity and prognosis of ACI.
出处
《医学临床研究》
CAS
2009年第5期869-871,共3页
Journal of Clinical Research