正常人与肺癌患者胸膜间皮细胞扫描电镜观察

Scanning electron microscopic observation of pleural mesothelioma in normal subjects and patients with lung cancer

应用扫描镜超微病理技术，分析对比了肺癌患者胸膜间皮细胞与正常人胸膜间皮细胞间超微形态的异同。结果显示：正常成人胸膜脏层间皮细胞轮廓清楚，间皮细胞表面布满高低不一的微嵴及微绒毛。肺癌患者间皮细胞肿胀，细胞表面微嵴消失且出现大量细胞孔，浆膜游离面有大量渗液。依据扫描电镜所见，作者提出肺表面间皮细胞改变是肺癌导致胸水形成的形态学基础。

The ultrastructures of pleural mesothelioma were compared between patients patients with lung cancer and normal subjects by pathological technique under scanning electron microscope. The results showed that in the normal subjects the contour of mesothelial cells of visceral pleura was clear,and their surface swarmed with high or low microridges and microvilli,while in the patients with lung can- cer the mesothelial cells were swollen, microridges disappeared, numerous plasmalemmal pores appeared on cellular surface, and pro-fuse exudate came out from the free surface of serosa. Based on the findings by scanning electron microscopy, the authors suggested the change of mesothelial cells on the surface of lungs is the morphologieal basis of pleural exudation in patients with lung canncer.