子宫内膜和卵巢原发性双癌的研究进展

Progress in study on synchronous primary endometrial and oVarian carcinomas

子宫内膜和卵巢原发性双癌在临床常与Ⅲ期子宫内膜癌或Ⅱ期卵巢癌相混淆，其发病年龄相对较低。发病机制可能与第2苗勒系统、子宫内膜异位症恶变、雌激素、基因突变等有关。临床上常根据Young和Scully的病理诊断标准，辅助免疫组化、DNA流式细胞仪检测、基因突变分析等明确诊断。原发性双癌患者往往预后较好。

Synchronous primary endometrial and ovarian carcinomas are not common but often are misdiagnosed as FIGO stage Ⅲ of endometrial carcinoma or FIGO stage Ⅱ of ovarian carcinoma. The women with synchronous primary endometrial and ovarian carcinomas are relatively young. The second mullerian system, canceration of endometriosis, estrogen as well as gene mutation may be associated with development of this disease. Clinically, the diagnosis was determined according to pathological diagnostic criteria recommended by Young and Scully adjuvant to immunohistochemistry, DNA flow cytometry detection and gene mutation analysis. The patients with synchronous primary carcinomas usually have a better prognosis.