甲醛致骨髓造血细胞遗传毒性研究展望

Expectation on the Studies of Molecular Mechanism for Genotoxicity of Indoor Air Pollutant Formaldehyde to Marrow Hematogenic Cells

甲醛是我国目前最主要的室内空气污染物.相当一部分新装修的房屋室内甲醛浓度超过安全标准,室内甲醛污染已成为中国的环境污染公害.2004年6月15日世界卫生组织下属的国际癌症研究局确认甲醛是人类致癌物,然而甲醛是否能导致人类白血病?该公报指出:虽然有流行病学的证据,但是由于致病机制并不清楚,需要做进一步的研究,才能得出结论.问题的关键是:甲醛或其衍生成分经血液向骨髓转移的分子机制,以及这些成分在骨髓中对微环境组分的作用机制.

Formaldehyde is currently the most important indoor air pollutants in China. Now it has been a China specific public hazard, and in part of the newly decorated housing the indoor formaldehyde concentrations exceeded safety standards. On 15 June, 2004, the International Agency for Research on Cancer of World Health Organization indicated formaldehyde is carcinogenic to humans. Whether formaldehyde can cause human leukemia or not？ The press release indicated： Although epidemiological evidence, but because pathogenic mechanism is not clear, it needs further study before we can draw conclusions. The key issue is how formaldehyde or its derivatives ingredients go through blood into bone marrow.