摘要
采用ELISA法测定102例2型糖尿病（T2DM）患者（其中54例合并大血管病变）、45例大血管病变患者及30例正常对照者的血清低密度脂蛋白免疫复合物（LDL-ICs）浓度。T2DM及大血管病变患者血LDL—ICs浓度均高于正常对照者，糖尿病合并大血管病变者高于单纯糖尿病、单纯大血管病变患者；血清LDL-ICs浓度与体重指数、血糖化血红蛋白、血压、总胆固醇、甘油三酯水平呈正相关，与高密度脂蛋白胆固醇水平呈负相关，与低密度脂蛋白胆固醇水平无相关性。LDL-ICs、血压、糖化血红蛋白是糖尿病大血管病变的危险因素。
This study was designed to observe the clinical value of low-density lipoprotein immune complexes （LDL-ICs） in patients with type 2 diabetes mellitus （T2DM）. Fifty-four patients with type 2 diabetes ＋maeroangiopathy （DM-MA group）, 48 patients with type 2 diabetes （DM group）, 45 patients with maeroangiopathy （MA group）, and 30 normal controls （NC group） were enrolled. LDL-ICs levels in the DM-MA group were significantly higher than those in the other three groups. The levels of LDL-ICs in the MA group were higher than those in the NC and DM groups. There was a significant difference in LDL-ICs between the DM and NC groups. LDL-ICs levels were positively related with body mass index （ BMI）, glycosylated hemoglobin Ale（HbAlc）, blood pressure, total cholesterol, and triglyceride. There was no significant relationship between low-density lipoprotein cholesterol and LDL-ICs. A significantly negative correlation was recorded between high-density lipoprotein cholesterol and LDL-ICs. Our study suggests that LDL-ICs, blood pressure, and HbAlc may be risk factors of macroangiopathy in type 2 diabetic patients.
出处
《中华全科医师杂志》
2009年第6期407-409,共3页
Chinese Journal of General Practitioners
基金
基金项目：江苏省南通市卫生局项目编号（W0410）
