体质指数与非吸烟女性肺癌关系的前瞻性队列研究

Body mass index and risk of lung cancer in no-smoking women:a prospective cohort study in urban Shanghai

目的:研究体质指数(body mass index,BMI)与非吸烟女性肺癌的关系。方法:建立1997—2000年上海市区74942人(其中非吸烟者72829人)、年龄40～70岁的女性队列,每2年随访1次,至2007年12月共收集271例非吸烟女性肺癌病例。用COX回归模型分析BMI与非吸烟女性肺癌发生的相对危险度(relative risk,RR)和95%可信区间(95%confidence interval,95%CI)。结果:调整年龄、教育程度、绝经状态等因素后,基线BMI、20岁BMI与非吸烟女性肺癌危险均无关。基线BMI最高四分组与最低组比较,RR=0.95(95%CI:0.67～1.34);20岁BMI最高四分组与最低组比较,RR=0.77(95%CI:0.52～1.15)。基线BMI和年龄与非吸烟女性肺癌之间关系的分层分析得到相似结果。结论:40岁以上非吸烟女性的BMI可能与其肺癌发生的危险性没有关联。

Objective：To investigate the association between BMI （Body Mass Index） and risk of lung cancer in non-smoking women in urban Shanghai.Methods：A total of 74 942 female residents aged 40 to 70 years in urban Shanghai were recruited in a prospective cohort from 1997 to 2000. They were actively followed up every two years. Until December in 2007, 271 incident cases of lung cancer in no smoking women were identified in the cohort. COX regression model was used to estimate the adjusted relative risks （RR） and 95% confidence intervals （95% CI）. Results：After adjustment for age, education level, menopause status and other potential confounding factors,there were no association of baseline BMI and 20-year BMI with risk of lung cancer. The highest quartiles of baseline BMI group experienced 0.95 fold risk （95%CI： 0.67-1.34） of lung cancer compared with their counterpart with lowest quartile. Compared with those with lowest quartile of BMI when aged 20 years, women who with the highest quartiles experienced 0.77 fold decreased risk （95%CI： 0.52-1.15）. Similar results were obtained after stratified analysis on the association of baseline BMI with risk of lung cancer in non-smoking women.Conclusion：BMI was not associated with the risk of lung cancer in no-smoking women older than 40 years in urban Shanghai.