儿童OSAHS患者血清IGF-1、IGFBP-3及甲状腺激素的检测及分析

Determination and analysis of serum IGF-1,IGFBP-3 and thyroid hormones in children with obstructive sleep apnea hyponea syndrome

目的检测分析阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患儿血清胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子结合蛋白-3（IGFBP-3）及甲状腺激素的水平变化及与OSAHS患儿生长发育的关系。方法选择2008年4～12月期间山东大学第二医院耳鼻喉科收治的OSAHS患儿25例及在门诊查体的健康儿童15例（对照组）,测量其身高、体重;血清IGF-1、IGFBP-3水平的检测采用ELISA法,血清TSH、FT3及FT4水平的检测采用放射免疫法。结果OSAHS组患儿身高、体重、体质量指数（BMI）、身高标准差得分（HtSDS）及体重标准差得分（WtSDS）与对照组儿童相比差异无统计学意义（P〉0.05）,但OSAHS组有2名患儿生长发育迟缓;OSAHS患儿血清IGF-1水平与对照组儿童相比差异无统计学意义（P〉0.05）,IGFBP-3水平比对照组儿童明显降低（P〈0.05）;血清TSH、FT3、FT4水平与对照组儿童相比差异无统计学意义（P〉0.05）。结论儿童OSAHS患者血清IGFBP-3水平降低,可能与OS-AHS患儿的生长发育迟缓有关。

Objective To study the levels of serum IGF-1, IGFBP-3 and thyroid hormones in children with obstructive sleep apnea hyponea syndrome and to explore the relations between their levels and growth of child patients with OSAHS. Methods 25 child patients with OSAHS and 15 healthy children were enrolled in this study. Height and weight were measured at first, then serum IGF-1 and IGFBP-3 levels were determined by ELISA, and serum thyroid hormones were determined by radioimmunoassay. Results There were no statistical differences for height, weight, BMI, HtSDS and WtSDS between the OSAHS children and the controls（ P 〉 0.05）, but two children with OSAHS had growth retardation. Serum level of IGF-1 had no significant statistical differences between OSAHS children and controls（ P 〉 0.05）. Serum level of IGFBP-3 had significant statistical differences between OSAHS children and controls（ P 〈 0.05）. Serum levels of TSH, FT3 and FT4 had no significant statistical differences between OSAHS children and the controls（ P 〉 0.05）. Conclusion These results indicate that some children with OSAHS have growth retardation, which may be related to the decrease of IGFBP-3 concentrations.