c-erbB-2与PTEN在子宫内膜癌中的表达及其相互关系的研究

Study of the expression and correlation of c-erbB-2 and PTEN in endometrial carcinoma

目的:探讨c-erbB-2与PTEN在子宫内膜癌中的表达及两者的相关性。方法:应用免疫组化SP法检测正常增生期子宫内膜、子宫内膜非典型增生及子宫内膜癌组织中c-erbB-2与PTEN的表达。结果:c-erbB-2在正常增生期子宫内膜、子宫内膜非典型增生及子宫内膜癌组织中的阳性表达率分别为0、40%、58%;PTEN的阳性表达率分别为100.0%、60.0%、25.8%。c-erbB-2在子宫内膜癌中的阳性表达率与肿瘤的病理组织分级呈正相关﹙P<0.05﹚,子宫内膜癌中的c-erbB-2与PTEN表达未见明显相关性。结论:c-erbB-2的阳性表达可能与患者的不良预后相关。PTEN表达的缺失在子宫内膜癌的早期发生中起着一定的作用。在子宫内膜癌的发生中,c-erbB-2与PTEN的负协同作用尚不能确定。

Objective： To study the expression and correlation of c-erbB-2 and PTEN in endometrial carcinoma. Methods： S-P immunobistoehemistry was used to measure the protein expressions of c-erbB-2 and PTEN in normal endometrium of proliferative phase, endometrial atypical hyperplasia and endometrial carcinoma. Results： The positive expression rate of c-erbB-2 in normal endometrium of proliferative phase, endometrial atypical hyperplasia and endometrial carcinoma were 0, 40% and 58% respectively; and those of PTEN were 100.0% and 60.0% and 25.8% respectively. The positive expression rate of c-erbB-2 in endometrial carcinoma and the histological differentiation were positively correlated （P〈 0.05）. There was no correlation between the expression rate of c-erbB-2 and PTEN in endometrial carcinoma. Conclusion： There is a correlation between the positive expression of c-erbB-2 and poor prognosis of patients. The deletion of PTEN expression may play a role in the earlier happening of endometrial carcinoma. In the happening of endometrial carcinoma, the inverse coordination with c-erbB-2 and PTEN is also uncertain.