遗传性非息肉病性大肠癌临床病理特点和预后分析

The analysis of clinicopathological feature and prognosis of hereditary non-polyposis colorectal cancer

目的:探讨遗传性非息肉病性大肠癌(HNPCC)的临床病理特点和预后。方法:选取1999年10月～2007年10月我院收治的遗传性非息肉病性大肠癌15家系60例患者组成HNPCC组,随机选取同期收治的散发性大肠癌58例组成散发组;回顾分析两组的临床病理和随访资料,比较两组的临床病理特点和预后差异。结果:HNPCC组和散发组在性别方面无显著差异,但在发病年龄、肿瘤部位、病理类型、肿瘤分期和预后方面差异显著。HNPCC具有发病年龄早、病理分化差、右半结肠多见、多原发癌多见的特点,但其5年生存率好于散发性大肠癌。结论:HNPCC的临床病理特点突出,其生物学行为与散发性大肠癌明显不同,预后比散发性大肠癌好。

Objective：To explore the clinical pathological feature and prognosis of hereditary nonpolyposis colorectal cancer （HNPCC）.Methods： Data of colorectal cancer patients admitted to our hospital from Oct 1999 to Oct 2007 were analyzed retrospectively. Patients were divided into HNPCC group and sporadic colorectal cancer （sporadic CRC） group. Clinicopathological feature and prognosis were compared between two groups.Results： The two groups had significant differentia not in sex; but in onset age, localization of tumor, pathological differentiation, clinical stage of tumor and prognosis. HNPCC group presented several particular clinicopathological features, such as early onset, frequent localization in proximal colon, proclivity of synchronous and metachronous tumors, excessive mucinous and poorly differentiated tumors, high incidence of extracolonic malignancies, and so on. But the prognosis of HNPCC group was better than sporadic CRC group. Conclusion：The clinicopathological feature of HNPCC is prominent. HNPCC and Sporadic CRC significantly differ in their biological behavior. The prognosis of patients with HNPCC is better than sporadic CRC.