自体血清皮肤试验在荨麻疹和湿疹病因诊断中的价值研究

The study of autologous serum skin test in the cause of urticaria and eczema

目的:进一步探讨自身免疫因素在荨麻疹、湿疹发病机制中的作用。方法:采用自体血清皮肤试验(ASST)对135例荨麻疹患者、79例湿疹患者及20例健康者进行检测。结果:荨麻疹、湿疹病例组ASST阳性率为31.8%,健康对照组阳性率为0,两组比较存在显著差异(P<0.05);荨麻疹与湿疹患者ASST阳性率分别为37.0%、22.8%(P<0.05);急性期与非急性期患者ASST阳性率分别为21.3%、38.1%(P<0.05)。结论:在部分荨麻疹和湿疹患者血清中存在自身抗体,疾病的发生有自身免疫机制的参与;自身免疫因素在荨麻疹发病中较其在湿疹发病中更具有意义,且自身免疫因素更主要是在疾病的慢性期发挥作用。

Objective： To further explore the factors in their own free urticaria, the pathogenesis of eczema. Methods： We took autologous serum skin test （ASST） of 135 cases of urticaria,79 cases of eczema patients and 20 healthy people tested. Results：214 cases of eczema in patients with urticaria ASST have detected 68 cases of positive,positive rate was 31.8o//00, the health of the control group were negative, there were differences between two groups （P〈0. 05）. One urticaria and eczema in patients with positive rates were 37.0% and 22.8% （P〈0.05） ,acute phase and non acute patients with positive rates were 21.3% and 38.1% （P〈0.05）. Conclusions： In some patients with urticaria and eczema with serum antibodies that exist in their own diseases were involved in autoimmune mechanism. Autoimmune urticaria factor in the incidence of eczema was more meaningful and more important one.