恶性血液病全血细胞减少的临床分布特点

The distribution of pancytopenia in malignant hematological disease

目的:探讨全血细胞减少在13种恶性血液病中所占的比例及发生率。方法:回顾655例初诊恶性血液病患者的外周血细胞检测结果,分析全血细胞减少患者在13种恶性血液病中所占比例及发生率。结果:655例患者中共有81例出现全血细胞减少,在13种恶性血液病中所占的比例由多到少依次为M4/M5、ALL、NHL、MF、M2、M7、M6、M1、MM、CML、HCL、M0、M3;髓系中M0、MF、M1、M7、M6、M4/M5、CML、M2和M3的发生率分别为75.0%、56.0%、50.0%、45.0%、33.0%、13.0%、9.0%、5.0%和3.0%,淋系中HCL、MM、NHL和ALL的发生率分别为50.0%、50.0%、36.0%和6.0%。结论:恶性血液病出现全血细胞减少与各类型疾病的临床发病率和各自病理特点有关。

Objective：To study distribution of pancytopenia in 13 kinds of malignant hematological diseases. Methods： Analyzing peripheral blood cells in 655 patients with malignant hematological disease, evaluating proportion of patients with pancytopenia in all patients and their incidence rate respectively. Results：81 out of 655 patients were involved pancytopenia at preliminary diagnosis. Number of patients with pancytopenia in M4/M5, ALL, NHL, MF. M2 M7, M6, M1, CML, HCL, M0, M3 were in reducing. In myeloid diseases, t he paneytopenia incidences of M0, MF, M1, M7, M6, M4/M5 ,CML,M2 and M3 were 75%,56%,50%,45%,33%,13%, 9%,5% and 3% respectively. While, of lymphoid disease as HCL,MM,NHL and ALL were 50%,50%,36 % and 6 % respectively. Conclusions： Paneytopenia involved in malignant hematological disease was not only related with disease incidence,but also associated with disease entity and their pathological characteristics.