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干细胞候选基因ABCG2在非小细胞肺癌中的表达及意义 被引量：1

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摘要 目的:探讨干细胞候选基因ABCG2在非小细胞肺癌组织中的表达及其临床意义。方法:用RT-PCR方法检测8例正常肺组织和48例非小细胞肺癌术后标本中ABCG2基因的表达情况,并分析其与临床病理特征的关系和对预后的影响。结果:ABCG2基因在8例正常肺组织中全部呈阳性表达,48例肺癌组织中22例呈阳性表达,表达率为45.8%(22/48),二者比较差异有统计学意义(P<0.01);ABCG2的表达在非小细胞肺癌各种临床病理特征中的比较差异无统计学意义(P>0.05);AB-CG2(+)组生存期短于ABCG2(-)组(P<0.05);ABCG2(+)组生存期有短于全组的趋势,ABCG2(-)组生存期有长于全组的趋势,但差异没有统计学意义(P>0.05)。结论:ABCG2的表达与非小细胞肺癌临床病理特征无关;ABCG2的表达情况是影响患者术后生存期的独立因子,阳性表达者预后较差。
作者 谢彤 茅乃权 刘德森 赵冰冰 黄鼎铭 左传田
机构地区 广西医科大学附属肿瘤医院胸外科
出处 《广西医科大学学报》 CAS 2009年第1期39-41,共3页 Journal of Guangxi Medical University
基金 广西科学基金资助项目(No.桂科青0728084) 广西壮族自治区研究生教育创新计划研究生科研创新项目(No.2006105981002D11)
关键词 非小细胞肺癌 ABCG2 肿瘤干细胞 SP细胞
分类号 R735.7 [医药卫生—肿瘤]
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参考文献9

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同被引文献11

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广西医科大学学报
2009年 第1期

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