缺氧缺血性脑病新生儿血清尿酸和C-反应蛋白水平的变化

Change of Urine Acid and C Reactive Protein in Serum of Newborns with Hypoxic Ischemic Encephalopathy

目的研究缺氧缺血性脑病(HIE)患儿血清尿酸(UA)和C-反应蛋白(CRP)水平的变化与临床意义。方法利用全自动生化分析仪检测56例HIE患儿(轻度24例,中重度32例)急性期及恢复期血清UA和CRP水平,并与18例正常足月新生儿作对照。结果HIE患儿急性期血清UA和CRP水平均高于对照组(P<0.01),恢复期与对照组比较UA间差异有统计学意义(P<0.05),而CRP差异无统计学意义(P>0.05);血清UA和CRP水平与病情的严重程度密切相关,中重度组高于轻度组(P<0.05)。结论血清UA和CRP的动态变化有协同性,且与HIE的病程相平行,能敏感地反映出HIE的病情轻重程度,血清UA和CRP水平可作判断病情及指导治疗的重要指标。

Objective To evaluate the change of UA and C - reactive protein （CRP） in serum of newborns with hypoxie ischemic encephalopathy. Methods Serum levels of UA and CRP was measured in 56 cases of newborns with hypoxic ischemic encephalopathy （24 cases of mild, 37 cases of moderate and severe status） by automantic biochemistry analyzer. Resuits Serum levels of UA and CRP in the HIE groups were obviously higher than that of the normal groups （ P 〈0.01 ）, There were statistically significant differences between the mild and moderate - severe groups （ all P 〈 0. 05）. Conclusion The present data suggest that the changes of serum levels of UA and CRP were correlated with severity of HIE. UA and CRP can be a good standard for the diagnosis of cardiac injury in the HIE.