蓝光照射治疗新生儿高胆红素血症的疗效和对甲状腺功能的影响

The Curative Effect and Influence of Hypothyroid Function for Hyperbilirubinemia by Phototherapy Treatment

目的探讨蓝光疗法治疗新生儿高胆红素血症对甲状腺功能的影响。方法新生儿高胆红素血症50例,按蓝光照射时间不同分为:治疗8h组(治疗组A)25例,治疗12h以上(治疗组B)25例,同时选取正常足月儿30例为对照组,观察2组治疗前后高胆红素血症的含量和蓝光照射对甲状腺功能的影响。结果双面蓝光治疗新生儿高胆红素血症显效28.0%,有效54.0%,无效18.0%,总有效率为82.0%;光疗后血清胆红素(190±29)μmol/L明显低于光疗前(264±25)μmol/L,差异有统计学意义(P<0.0.5);光疗后发生皮疹16.0%、发热12.0%、腹泻8.0%、精神疲乏8.0%、哺乳能力下降8.0%、皮肤损伤12.0%;光疗前后甲状腺功能指标变化差异无统计学意义(P>0.05)。结论蓝光照射治疗新生儿黄疸安全有效,对甲状腺功能无影响,对甲状腺不必采取特殊保护措施。

Objective To compare the influence of hypothyroid function in neonatal with hyperbilirubinemia by blue - light treatment way. Methods 50 cases with Neonatal hyperbilirubinemia according to the different Blu - ray irradiation time were divided into： 8h treatment group （treatment group A） 25 cases, treatment for more than 12h （treatment group B） 25 cases, at the same time to select 30 cases of normal full - term infants as a control group, Observation of group 2 before and after treatment of hyperbilirubinemia in the content and influence of Blu - ray irradiation on thyroid function. Results The rate of markedly, effective, invalid, total effective were 28. 0, 54. 0, 18.0%, 82.0%, respectively; The contents of serum bilirubin after phototherapy （ 190. 48 ± 28. 75 ） μmol/L were significantly lower than before phototherapy （264. 38 ±25.47 ） mol/L （ t = 2. 234, P 〈 0. 0.5 ） ; The rash, fever, diarrhea, mental fatigue, decline in breast - feeding capacity, skin lesions were 16. 0%, 12. 0%, 8.0%, 8.0%, 8.0%, 12. 0% respectively; The change of hypothyroid function after and before treatment had no statistical meaning （ P 〉 0.05）. Conclusion Phototherapy is efficacious and safe for the treatment of neonatal jaundice. The change of thyroid function was no influence.