骨肉瘤、骨巨细胞瘤姊妹染色体互换的临床研究

A clinical research on the SCE and chromosomal mutation of osteosarcoma and giant cell tumor

作者对骨肉瘤和骨巨细胞瘤患者淋巴细胞姊妹染色体互换（SCE）值进行了研究，探讨了SCE检测技术在骨肿瘤临床诊断和病理学及预后的关系。结果显示，骨肉瘤SCE值明显高于正常对照组，有显著性统计学意义。骨巨细胞瘤SCE频率增高与病理学分级呈正相关。恶性骨肿瘤染色体稳定性差，DNA容易损伤断裂。该研究可能对骨肿瘤早期诊断、防治提供潜在的临床应用价值。

The relationships between lymphocyte SCE as well as chromosomal mutation and diagnosis, pathology and prognosis of bone tumor are studied by detecting lymphocyte SCE and chromosomal mutation rate in the patients with osteosarcoma and giant cell tumor. The results showed that the SCEand chromosomal mutation rate of the patients with osteosarcoma are statistically and significantly higherthan those of normal individuals, and there is a positive relationship between the giant cell tumor SCE frequency and its pathological grades. The chromosomes of the patients with malignant bone tumor are lessstable and the DNA is easy to be damaged and broken. This study probably has a potential clinical valueIn the early diagnosis, prevention and treatment of malignant bone tumor.