CEA、NSE、CY21-1、GLU在结核性、恶性胸腔积液鉴别诊断中的意义

Clinical significance of CEA,NSE,CY21-1 and GLU in the differential diagnosis of tuberculous effusion and malignant pleural effusion

目的探讨癌胚抗原（CEA）、神经特异性烯醇化酶（NSE）、细胞角蛋白19片断（CY21-1）、葡萄糖（GLU）在结核性和恶性胸腔积液鉴别诊断中的价值。方法用电化学发光免疫分析法定量测定42例肺癌伴胸腔积液（恶性）和54例结核性胸腔积液（良性）患者胸腔积液中CEA、NSE、CY21-1、GLU含量。结果恶性胸腔积液组CEA、NSE、CY21-1、GLU均明显高于结核性胸腔积液组（P〈0.05）。CEA、NSE、CY21-1敏感性分别为64.3%、26.2%、57%,特异性分别为94.4%、94.4%、80.4%;三项联合检测的敏感性为90.5%,特异性83.3%。结论联合检测胸腔积液中CEA、NSE、CY21-1、GLU的含量对结核性和恶性胸腔积液的诊断和鉴别诊断有一定的价值。

Objective To explore the differential diagnosis value of CEA,NSE,CY21-1 and GLU in tuberculous effusion（TE） and malignant pleural effusion（MPE）.Methods The levels of the four markers in 42 cases of MPE and 54 cases of TE were detected by electrochemilumin-escence immunoassay.Results The levels of four markers in MPE group were significantly higher than that in TE group（P 〈 0.05）.The sensitivity for each marker of CEA,NSE,CY21-1 in the diagnosis of MPE was 64.3%,26.2%,57%,respectively,specificity was 94.4%,94.4%,80.4%,respectively.Combined three markers in the detections of in MPE,the sensitivity and specificity were 90.5% and 83.3%,respectively.Conclusion Combined detection of four markers of CEA,NSE,CY21-1 and GLU has significant value in the differential diagnosis of TE and MPE.