先天性神经管缺陷35例临床分析

Analysis of clinical data of 35 cases of congenital neural tube defact

目的了解横县地区神经管缺陷发生特点及相关因素。方法收集广西横县6年间住院分娩监测为神经管缺陷的35例临床资料作回顾性分析。结果35例中无脑儿20例,脑膨出8例,脊柱裂7例,发生人数占同期出生缺陷总人数的3.88%。产前超声诊断率74.2%,产后诊断率25.7%。相关因素与母亲职业、文化水平、孕前和孕期保健不足、没有使用叶酸预防、接触有毒有害物品与环境等有关。结论婚前检查,普及孕前孕期教育,指导孕妇正确服用叶酸,避免接触有毒有害物品,提高产前超声诊断率等,是减少神经管缺陷出生的关键。

Objective To investigate the features of occurrence of neural tube defect in Heng county and its relevant factors.Methods The clinical data of 35 cases of neural tube defect discovered in hospitalization parturition monitoring during a period of 6 years were collected and were a retrospectively analysed.Results Out of 35 cases 20 cases were anencephalus,8 were encephalocele,7 were spina bifida,the number of occurrence accounted for 3.88% of the total number of birth defect of the same period.Antenatal ultrasonic diagnosis rate was 74.2%,puerperal diagnosis rate was 25.7%.The relevant factors included occupation,educational background,lack of health care before and during pregnancy,no prevention by taking folic acid,contact with toxic and deleterious article and environment.Conclusion It is key to reduction of the occurrence of neural tube defect to popularize pre-pregnancy and pregnancy education,instruct the pregnant women to correctly take folic acid and keep away from contact with toxic and deleterious article,and improve antenatal ultrasonic diagnosis rate through prenuptial checkup.