活化白细胞黏附分子与肿瘤

Activated leukocyte cell adhesion molecule and tumors

活化白细胞黏附分子（ALCAM）是免疫球蛋白基因超家族成员，主要表达在白细胞和胸腺上皮细胞。ALCAM在细胞间异嗜性黏附和同嗜性黏附中起重要作用。研究表明，ALCAM在多种肿瘤细胞表面高表达，参与肿瘤的发生发展，在人类肿瘤，ALCAM的表达与乳腺癌、食管癌、结肠癌、卵巢癌、肝癌及恶性黑色素瘤等密切相关。

Activated leukocyte cell adhesion molecule （ALCAM）is a member of immunoglobulin gene superfamily. It is manily expressed in leucocytes and thymic epithelial cells. ALCAM mediates both heterophilic （ ALCAM- CD6） and homophilic （ ALCAM- ALCAM） cell- cell interactions. Studies show that ALCAM is highly expressed on multiple tumor cells and plays a role in tumorigenesis and tumor progression. ALCAM expression is closely correlated with several human tumors,including breast cancer, esophageal carcinoma, colon carcinoma, ovarian cancer, hepatocellular carcinoma and malignant melanoma.