摘要
活化白细胞黏附分子(ALCAM)是免疫球蛋白基因超家族成员,主要表达在白细胞和胸腺上皮细胞。ALCAM在细胞间异嗜性黏附和同嗜性黏附中起重要作用。研究表明,ALCAM在多种肿瘤细胞表面高表达,参与肿瘤的发生发展,在人类肿瘤,ALCAM的表达与乳腺癌、食管癌、结肠癌、卵巢癌、肝癌及恶性黑色素瘤等密切相关。
Activated leukocyte cell adhesion molecule (ALCAM)is a member of immunoglobulin gene superfamily. It is manily expressed in leucocytes and thymic epithelial cells. ALCAM mediates both heterophilic ( ALCAM- CD6) and homophilic ( ALCAM- ALCAM) cell- cell interactions. Studies show that ALCAM is highly expressed on multiple tumor cells and plays a role in tumorigenesis and tumor progression. ALCAM expression is closely correlated with several human tumors,including breast cancer, esophageal carcinoma, colon carcinoma, ovarian cancer, hepatocellular carcinoma and malignant melanoma.
出处
《国际肿瘤学杂志》
CAS
2009年第4期245-247,共3页
Journal of International Oncology