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NgR靶向治疗胶质瘤的分子生物学机制

Biological mecbanisms of NgR on target therapy for glioma
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摘要 神经轴突生长抑制因子受体（NgR）是髓鞘相关抑制因子Nogo-A、髓鞘相关糖蛋白（MAG）和少突胶质细胞髓鞘糖蛋白（OMgp）的共同作用途径。NgR在胶质瘤细胞黏附迁移、凋亡、神经干细胞分化及血管再生重塑等方面发挥着重要作用，有望成为针对神经胶质瘤进行分子靶向治疗的关键分子。 Nogo-66 receptor（NgR） is the common way for three myelin-associated inhibitors Nogo-A, myelin associated glycoprotein（MAG） and oligodendrocyte-myelin glycoprotein（OMgp）. NgR plays an important role in cell adhesion and migration ,apoptosis ,differentiation of neural stem cells,angiogenesis and vascular remodeling. NgR may be a key molecule of the molecular target therapy for glioma.
作者 李帅(综述) 熊南翔(审校) 赵洪洋(审校)
机构地区 华中科技大学同济医学院附属协和医院神经外科
出处 《国际肿瘤学杂志》 CAS 2009年第4期267-269,共3页 Journal of International Oncology
基金 国家自然科学基金资助项目（30471775,30801180）
关键词 神经胶质瘤 生物疗法 神经轴突生长抑制因子受体 Glioma Biological therapy Nogo-66 receptor
分类号 R373.21 [医药卫生—病原生物学] R734.2 [医药卫生—肿瘤]
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国际肿瘤学杂志
2009年 第4期

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