摘要
基因标签的研究共性问题包括:①临床验证,包括各模型在独立资料中的验证、多个模型在同一组资料中共同验证、两个重要的前瞻性验证研究的基本信息;②在判断乳腺癌患者预后、判断诱导化疗疗效和指导术后辅助化疗方面的价值;③与传统的临床病理学评价体系比较的优缺点。
The commonness of gene signature include ( 1 ) the clinical validation: validation of separate models in independent data, validation of different gene signature models in the same protocol, and some basic information of two ongoing prospective studies; ( 2 ) the value of evaluating the prognosis of breast cancer patients, predicting the effectiveness of neoadjuvant chemotherapy, and guiding adjuvant chemotherapy; ( 3 ) the advantages and disadvantages compared with clinicopathological system.
出处
《国际肿瘤学杂志》
CAS
2009年第4期280-282,共3页
Journal of International Oncology
关键词
乳腺肿瘤
预后
治疗
基因标签
Breast neoplasms
Prognosis
Therapy
Gene signature