晚期胃癌的化疗及分子靶向治疗

Chemotherapy and molecular targeted therapy in advanced gastric cancer

在晚期胃癌的一线化疗方案中，蒽环类药物＋铂类药物＋氟尿嘧啶类药物组成的方案依然具有疗效和安全性；紫杉类药物＋铂类药物＋氟尿嘧啶类药物组成的化疗方案疗效和毒性并存；以S-1为基础的化疗方案显示了有效性和安全性。氟尿嘧啶类药物在非一线方案以及体力状况较差的患者中有效且安全。分子靶向药物联合化疗具有临床获益。疗效预测分子对选择化疗药物或分子靶向药物具有重要的意义。

In the first-line chemotherapy of advanced gastric cancer, the combination of anthracycline plus cisplatin/oxaliplatin plus fluorouracil still works in an effective and safe way. The combination of paclitaxel/docetaxel plus cisplatin/oxaliplatin plus fluorouracil has two sides. The therapy based on S-1 shows its effect and safety. In the non-first-line chemotherapy and therapy targeted on weak patients ,fluorouracil is an effective and safe solution. The combination of chemotherapy and molecular targeted therapy has clinical benefit. The selection of chemotherapy medicine or molecular targeted drug based on predictive molecule is of great significance.