血清Ⅳ型胶原测定在肾脏及呼吸道疾患中的应用

Determination of IV type collagen in renal and respiratory tract diseases

目的：了解血清Ⅳ型胶原（CL—Ⅳ）测定在非肝脏疾患中的临床价值．方法：采用双抗体夹心固相酶免疫法检验慢性阻塞性肺病（COPD）患者、慢性肾炎患者及尿毒症患者血清CL—Ⅳ水平。结果：尿毒症组血清CL—Ⅳ明显高于健康对照组，慢性肾炎组较对照组虽有升高，但并无显著性差异，COPD组较对照组并未免显著性升高。结论：血清CI—Ⅳ测定也是监测肾病变进展程度一个较好的指标。

objective To discuss the clinical value of IV type collagen in non - hepatic diseases. Methods UseEIA method to determine the level of IV type collagen in COPD and chronic renal failure patients. Results theuremic group was much higher than Control group. The chronic nephritis group was higher but had no signifi-cant deviation. The COPD group had no rise. Conclusion IV type collagen can be also used as a good index forevaluating the process of renal disease.