复方丹参注射液治疗百草枯中毒致肺损害临床效果研究

Clinical Curative Effect of Compound Danshen Injection on Paraquat Poisoning-induced Lung Injury

目的观察复方丹参注射液治疗百草枯中毒患者的效果。方法临床观察设常规治疗组(对照组)和复方丹参注射液加常规治疗组(观察组)。临床观察X线胸片、血气、肝肾功能和病死率。结果临床出现严重肺损害(肺门结构紊乱、肺纤维化等)的病例观察组占41.9%,对照组67.6%。两组差异有统计学意义(P<0.05)。观察组治疗前后PaO2增高,SGPT、总胆红素和Cr降低;而对照组仅Cr明显降低。观察组病死率占48.3%;对照组病死率占61.7%,两组比较差异有统计学意义(P<0.05)。结论复方丹参与综合治疗对改善百草枯中毒致肺损害、降低病死率有一定疗效。

Objective To observe the clinical therapeutic effect of compound Danshen injection on patients with lung in- jury induced by paraquat poisoning. Methods The clinical therapeutic effect was observed between conventional therapy group （control group） and compound Danshen injection plus routine treatment group （observation group）. X- ray, blood gas, liver and kidney function, and mortality were observed and compared between the two groups. Results The clinical emer- gence of serious lung damage （including hilar structure disorders, pulmonary fibrosis, etc. ） accounted for 41.9 % cases of ob- servation group, and 67.6 % cases of control group. There was a statistically significant difference between the two groups （P 〈0.0.5）. After treatment, PaO2 increased, while SGPT, total bilirubin and Or decreased in observation group. Only Or de- clined significantly in control group. The mortality was 48.3 % in observation group and 6I. 7 % in control group, the difference was statistically significant between the two groups （P 〈 0.05）. Conclusions Compound Danshen injection plus routine treatment can improve lung injury induced by paraquat poisoning and reduce the mortality.