岳阳地区头孢他啶使用量与鲍曼不动杆菌耐药性的相关性分析

Correlativity Analysis on Consumption of Ceftazidime and Drug Resistance of Acinetobacter baumannii in Yueyang

目的了解本地区抗菌药物尤其是头孢他啶使用量的变化,探讨其对鲍曼不动杆菌(Ab)耐药情况的影响。方法统计本地区2007-2008年用药人/次排序列前9位的抗菌药物使用量与Ab耐药率,并进行相关性分析。结果头孢他啶使用量与下季度Ab对头孢他啶和其它7种抗菌药的耐药率呈线性关系(P<0.05),其它结果差异无统计学意义。结论头孢他啶的使用量与Ab对多种抗菌药物耐药性的发展有关。

Objective To study the change of consumption of antibacterial agents, especially the ceftazidime and its effect on drug resistance of Acinetobacter baumannii （Ab）. Methods The consumption of the top ten antimicrobial agents in terms of person/times of medication from 2007 to 2008 in a hospital and its correlation with the drug resistance of Acineto- bacter baumannii were analyzed. Results A linear correlation was noted between the consumption of ceftazidime and resis- tance of Pseudomonas aeruginosa to ceftazidime and other seven antimicrobial agents in the next quarter （P〈 0.05）, howev- er, there was no statistically significant difference among all the other results. Conclusions The consumption of ceftazi- dime is associaied with resistance of Acinetobacter baumannii to multi - kinds of antibacterials.