大肠癌PCNA和BCL-2表达预后价值

PROGNOSTIC EVALUATION OF PCNA AND BCL-2 EXPRESSION OF COLORECTAL CARCINOMA

该文应用免疫组化方法检测42例有随访资料的大肠癌石蜡标本增殖细胞核抗原（PCNA）和B细胞性淋巴瘤－2（BCL－2）的表达。结果表明：正常大肠粘膜表面上皮PCNA和WIL－2表达均为阴性，而PCNA和BCL－2在大肠癌组织均有较高表达，且PCNA在大肠癌中表达强弱与患者术后复发时间、死亡时间、肿瘤分化程度、淋巴转移和Dukes分期有明显正相关关系（P＜0．05），而与发病年龄、性别、肿块部位无关。BCL－2表达与肿瘤分化程度呈极显著正相关关系（P＜0．001），而与患者术后复发时间、死亡时间、淋巴转移、Dukes分期、年龄、性别及肿块部位无明显相关关系（P＜0．05）。结果表明：PCNA和BCL－2在大肠癌组织中均有较高表达，PCNA表达强弱与患者术后复发时间、死亡时间、肿痛分化程度、淋巴结转移及患者Dukes分期呈显著正相关关系。该指标对大肠癌患者临床诊治和预后评估有较重要意义。

Utilizing immunohist ochemical methods, the expressions of PCNA and BCL- 2 from formalin-fixed and paraffin-embeded specimens of 42 Patients with colorectal carcinoma during a follow-up (three years later) were analyzed. The results show that the expressions of PCNA and BCL - 2 are negative in normal colorectal mucosae but positive in colorectal carcinoma. PCNA demonstrated a positive correlation (P < 0. 05) with the recurrence and death time of a patient, tumor stage, and lymph metastasis, but a negative correlation with patien's age, gender, and tumor location. BCL - 2 only shared a highly positive correlation (P< 0. 001) with tumor stage and no obvious correlation (P >0. 05) with such factors as recurrence time, death time, lymph metastasis, age, sex, and tumor location. All thase festures are important for clinical treatment and prognostic evaluation of colorectal carcinoma.