CD147和MMP-2、VEGF在腺样囊性癌侵袭转移中的作用

Expressions of CD147,MMP-2 and VEGF in the invasion and metastasis of adenoid cystic carcinoma

目的:研究CD147和基质金属蛋白酶-2(MMP-2)、血管内皮生长因子(VEGF)在腺样囊性癌(adenoid cystic carcinoma,ACC)组织中的表达和意义。方法:采用免疫组化EnvisionTM法检测72例ACC组织中CD147和MMP-2、VEGF的表达情况,结合临床病理资料进行统计分析。结果:CD147和MMP-2、VEGF在ACC组织中高表达,阳性表达率分别为62.5%、65.3%、73.6%;三者的表达均与肿瘤病理分型和临床分期有关(P<0.05),而与患者的性别、年龄无明显关联(P>0.05);神经侵袭组的CD147和MMP-2表达明显强于无神经侵袭组(P<0.05),VEGF在有无神经侵袭组间的表达无统计学差异(P>0.05);血管侵袭组和肿瘤发生转移组的CD147和MMP-2、VEGF的表达均明显强于对应组(P<0.05);CD147的表达与MMP-2和VEGF的表达具有显著相关性(P<0.001)。结论:CD147和MMP-2、VEGF的表达与ACC的侵袭转移密切相关,检测三者的表达有助于对ACC进行临床病理研究及转移潜势预测。

Objective： To evaluate the expressions of CD147, MMP-2 and VEGF in the invasion and metastasis of adenoid cystic carcinoma （ACC）. Methods： The expressions of CD147, MMP-2 and VEGF were detected by immunohistochemical method （ Envision^TM method） in 72 cases of ACC. The relationship between the expressions and clinieopathologic parameters were analyzed. Results： The expression rates of CD147, MMP-2 and VEGF in ACC tissues were 62.5% , 65.3% and 73.6% respectively; The expressions of CD147, MMP-2 and VEGF were correlated with tumor histopathologic type and clinical stage（ P 〈 0.05 ）, but not with patients＇age and gender （ P 〉 0.05 ） ; The expressions of CD147 and MMP-2 in perineural invasion group were stronger than those in negative perineural invasion group（P 〈 0.05 ） ; The expressions of CD147, MMP-2 and VEGF were significantly stronger in vascular invasion group and metastasis group when compared with control group（P 〈 0. 05 ） ; Significant correlation existed between the expressions of CD147 and MMP-2, VEGF（P 〈 0. 001 ）. Conclusion： Expressions of CD147, MMP-2 and VEGF play an important role in the invasion and metastasis of ACC. Detection of their expressions may useful to clinical and pathological study and metastasis predicting of ACC.