2型糖尿病患者血清C反应蛋白水平与牙周病关系

The relationship between serum C-reactive protein levels in type 2 diabetic patients and periodontal diseases

目的:检测2型糖尿病伴牙周病患者血清高敏C反应蛋白(hs-CRP)水平的变化,探讨2型糖尿病患者血清hs-CRP与牙周病的关系。方法:选择2型糖尿病伴重度牙周病患者共20例,2型糖尿病无牙周病组20例,健康对照组20例。采用免疫浊度法测定所有研究对象血清hs-CRP水平,同时测定体重指数、糖化血红蛋白等临床和生化指标。结果:2型糖尿病伴重度牙周病组血清hs-CRP水平显著高于2型糖尿病无牙周病组和健康对照组,2型糖尿病无牙周病组显著高于健康对照组(P<0.05);血清hs-CRP与Homa-IR、HbA1C呈正相关。结论:牙周病可能导致2型糖尿病患者血清hs-CRP水平增高,这种炎性因子可能加重糖代谢紊乱和胰岛素抵抗。

Objective：To investigate serum high sensitive C-reactive protein levels in type 2 diabetic patients with periodontal diseases, and to explore the relationship between serum high sensitive C-reactive protein levels and periodontal diseases in type 2 diabetic patients. Methods ： The study included 20 type 2 diabetic patients with moderate or severe periodontal diseases, 20 type 2 diabetic patients without periodontal diseases and 20 normal as control. Serum hs-CRP, HbAlc and other biochemical parameters were detected. Results： Compared with normal control and type 2 diabetic subjects without periodontal diseases, serum hs-CRP levels in type 2 diabetic patients with moderate or severe periodontal diseases were significantly increased. Serum hs-CRP levels were significantly elevated in type 2 diabetic patients without periodontal diseases compared with normal control subjects（P 〈 0.05 ） , The serum hs- CRP levels were positively associated with Homa-IR, HbA1C. Conclusion： Periodontal diseases result in higher circulating CRP in type 2 diabetic patients, and may aggravate glucose metabolic disorder and insulin resistance.