荧光分子断层成像系统的研究进展与比较

The Advance and Comparisons of Fluorescence Molecular Tomography Systems

荧光分子断层成像(FMT)利用具有特异性的荧光分子探针,在体成像、观测生物体内细胞和分子水平的变化。介绍FMT系统的国内外研究进展,从系统的复杂性、投影数目、光源-探测器(S-D)数据对集大小、重构图像的质量等方面,分析5种S-D几何结构的特点。着重从实现方面,分析、比较已报道的几种FMT系统的特点,并对其多模态成像的可扩展性、临床应用的可能性等进行了总结与展望。

With specific fluorescence probe, fluorescence molecular tomography images and surveys the changes of organisms in vivo at cell and molecular level. In this paper specialties of some reported continuous wave FMT systems were analyzed and compared. After the advances of FMT systems were introduced, feathers of five kinds of source- detector configurations were analyzed on aspects of the systems＇ complicacy, the projections＇ amounts, source- detector dataset＇s sizes and the reconstructed images＇ qualities. And the merits and shortcomings were presented of the reported FMT systems, which were implemented differently. Finally the feasibilities of the systems were explored and prospected for multimodality imaging and clinical practice.